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Our pet-friendly hotel in Sioux Falls, SD offers spacious and comfortable suites with full kitchens at a fantastic location off of I-29 next to the Empire Mall and entertainment venue, The District. The Marriott hotel is a short commute to a number of area health systems including: Avera McKennan Hospital and University Health Center, Sanford USD Medical Center and the Sioux Falls VA Hospital. We are only minutes away from the Sioux Falls airport, Augustana College, Southeast Technical Institute & the University of Sioux Falls. Enjoy the local attractions which includes: Falls Park, Denny Sanford Premier Center, Sioux Falls Arena, Orpheum Theater, Sioux Falls Convention Center & Sanford Pentagon. Enjoy some of the local sports scene, including USHL's Sioux Falls Stampede, NBADL's Sioux Falls Skyforce & minor league baseball Sioux Falls Canaries. Whether you are seeking a hotel in Sioux Falls because of business or leisure travel, you will find a home away from home at the Residence Inn.