Hotels in Santa Ana, Panama City

KAYAK searches hundreds of travel sites at once for hotels in Santa Ana

Here is why travellers choose KAYAK

Free to useThere are no hidden charges or fees.

Filter your dealsFilter by free cancellation, free breakfast and more.

Millions of reviewsCheck ratings based on millions of real guest reviews.

Bundle and saveSave money when you bundle your flight + hotel.

Recommended by KAYAK
Booking Insights
Recommended by KAYAK

Best hotels in Santa Ana (Panama City)

Hotel República Panamá - Panama City - Bedroom
Hotel República Panamá
0.2 mi from Santa Ana, Panama City, Panama
7.3Good(1256)
Free Wi-Fi
Air conditioning
£20+
Check availability
La Manzana by Wynwood House - Panama City - Living room
La Manzana by Wynwood House
0.3 mi from Santa Ana, Panama City, Panama
8.7Very Good(15)
Apartment
Air conditioning
£96+
Check availability
Hotel Riazor - Panama City - Bedroom
Hotel Riazor
0.3 mi from Santa Ana, Panama City, Panama
4.4Mediocre(4)
Free Wi-Fi
Air conditioning
£33+
Check availability
Casa Quijano 06 By Wynwood House - Panama City - Living room
Casa Quijano 06 By Wynwood House
0.3 mi from Santa Ana, Panama City, Panama
Apartment
£158+
Check availability
Hostal La Cigarra - Panama City - Living room
Hostal La Cigarra
0.2 mi from Santa Ana, Panama City, Panama
6.4Okay(5)
£23+
Check availability
Art Casco The Hotel - Panama City - Front desk
Art Casco The Hotel
0.3 mi from Santa Ana, Panama City, Panama
4.1Mediocre(17)
£27+
Check availability
Apartamento en el Corazón de Casco Viejo Panamá 8 - Panama City - Living room
Apartamento en el Corazón de Casco Viejo Panamá 8
0.3 mi from Santa Ana, Panama City, Panama
8.2Very Good(13)
Apartment
Free Wi-Fi
Air conditioning
£116+
Check availability
Amazing experience in Casco Viejo historical site 3 - Panama City - Bedroom
Amazing experience in Casco Viejo historical site 3
0.2 mi from Santa Ana, Panama City, Panama
8.0Very Good(4)
Apartment
Free Wi-Fi
Air conditioning
£72+
Check availability
Confortable mini loft en PH Casco View - Panama City - Dining room
Confortable mini loft en PH Casco View
0.4 mi from Santa Ana, Panama City, Panama
9.2Wonderful(5)
Apartment
Free Wi-Fi
Pool
Air conditioning
£57+
Check availability
2Rcondo balcony Surrounded by history with Modern Amenities - Panama City - Patio
2Rcondo balcony Surrounded by history with Modern Amenities
0.3 mi from Santa Ana, Panama City, Panama
8.7Very Good(12)
Apartment
Free Wi-Fi
Air conditioning
£57+
Check availability
Beautiful boutique Apart-hotel-views and service(Casco Antiguo) - Panama City - Living room
Beautiful boutique Apart-hotel-views and service(Casco Antiguo)
0.4 mi from Santa Ana, Panama City, Panama
Apartment
Air conditioning
£152+
Check availability
Hotel Doral - Panama City
Hotel Doral
0.2 mi from Santa Ana, Panama City, Panama
7.3Good(637)
Free Wi-Fi
Air conditioning
£21+
Check availability
Casco View Life - Panama City
Casco View Life
0.3 mi from Santa Ana, Panama City, Panama
8.9Very Good(69)
Free Wi-Fi
Pool
Pet-friendly
Air conditioning
£89+
Check availability
Hotel Caracas - Las Cumbres
Hotel Caracas
0.3 mi from Santa Ana, Panama City, Panama
7.5Good(1362)
Free Wi-Fi
Air conditioning
£39+
Check availability
Amazing 1 Bedroom in Casco Viejo - Panama City
Amazing 1 Bedroom in Casco Viejo
0.4 mi from Santa Ana, Panama City, Panama
9.0Wonderful(16)
Apartment
Parking
Free Wi-Fi
Pool
Air conditioning
£81+
Check availability
CASCO 114, king bed Stylish and Cozy apartment near Casco - Panama City
CASCO 114, king bed Stylish and Cozy apartment near Casco
0.4 mi from Santa Ana, Panama City, Panama
9.0Wonderful(4)
Apartment
Free Wi-Fi
Pool
Pet-friendly
Air conditioning
£63+
Check availability
Maison Boheme - La Manzana Panama - Panama City
Maison Boheme - La Manzana Panama
0.3 mi from Santa Ana, Panama City, Panama
8.8Very Good(40)
Apartment
Parking
Free Wi-Fi
Air conditioning
£70+
Check availability
La Manzana By Wynwood House - Albrook
La Manzana By Wynwood House
0.3 mi from Santa Ana, Panama City, Panama
7.5Good(9)
Apartment
Parking
Free Wi-Fi
Air conditioning
£63+
Check availability
Cozy Apartment Pool Coworking - Panama City
Cozy Apartment Pool Coworking
0.4 mi from Santa Ana, Panama City, Panama
9.8Wonderful(7)
Apartment
Parking
Free Wi-Fi
Pool
Air conditioning
£98+
Check availability
Hostal Cigarra - Panama City
Hostal Cigarra
0.2 mi from Santa Ana, Panama City, Panama
7.4Good(36)
Free Wi-Fi
Pet-friendly
Air conditioning
£20+
Check availability
Booking Insights

KAYAK’s insights for hotels in Santa Ana

Discover seasonal trends, ideal booking windows, and other data-driven tips to plan your stay in Santa Ana with confidence.

Which month has the cheapest hotel rates in Santa Ana?

Hotels are cheapest in Santa Ana in February, with average rates of £18. In comparison, November is the most expensive month, with prices at £59.

What is the cheapest day of the week to book a hotel in Santa Ana?

Tuesday offers the lowest rates in Santa Ana, with an average nightly price of £20. The highest prices are found on Thursday, with average rates at £86.

Find deals

How much is a Santa Ana hotel?

Here are our most popular & best value hotels

Good to know

Low season

High season

February
November
Cheapest month to stay with an average 21% drop in price.
Most expensive month to stay with an average 164% rise in price.

Top tips for finding a hotel deal in Santa Ana

  • Not sure just how much there is to see and do in Santa Ana? KAYAK users usually book their hotel here for 5 days.

FAQs when booking a hotel in Santa Ana

  • What are the best hotels in Santa Ana?

    Santa Ana is a great part of Panama City to make your base. If you’re staying in Santa Ana area then Hotel República Panamá, Hostal Goce, and Hostal La Cigarra are all recommended on KAYAK.

Where to stay in Santa Ana?

Our map will help you find the perfect hotel in Santa Ana, Panama City by showing you the exact location of each hotel.

What Santa Ana hotel guests are talking about

Show all

Popular topics

Hotels about topic

Show all
Hotel República Panamá - Panama City - Bedroom
Hotel República Panamá
0.2 mi from Santa Ana, Panama City, Panama
7.3Good(1256)
Free Wi-Fi
Air conditioning
£20+
Check availability
Hotel Doral - Panama City
Hotel Doral
0.2 mi from Santa Ana, Panama City, Panama
7.3Good(637)
Free Wi-Fi
Air conditioning
£21+
Check availability

Everything you need to know for your stay in Panama City