Enjoy Our Cherokee, NC Hotel's Mountain Location Savor the crisp mountain air and beautiful scenic views while staying at the Holiday Inn Express® Cherokee Casino Hotel. Situated in the heart of the Great Smoky Mountains in picturesque Cherokee, NC, our lodging provides excellent services and amenities along with a great location. As one of the leading hotels in Cherokee, NC for corporate travelers. While lodging with us, visitors can enjoy the non-stop action on Harrah's Cherokee Casino's glittering gaming floor or watch the breathtaking drama of Unto These Hills nearby. Take a ride through the mountains on the Great Smoky Mountain Railroad, or explore the Cherokee Indian Museum. This area boasts awesome outdoor recreation opportunities, which range from fly fishing and whitewater rafting to hiking and kayaking. Besides using the free high-speed internet access in our hotel's accommodation, guests in Cherokee, NC can take advantage of the complimentary, hot Express Start breakfast bar, which features our signature cinnamon rolls. And thanks to our on-site fitness center, it's easy to follow your workout routine. Call and reserve your room today!