£1,061 Find Cheap Flights from Southampton to South America – Compare and Save

This is the cheapest return flight price found by a KAYAK user in the last 72 hours by searching for a flight from Southampton to South America departing on 8/11. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Southampton to South America

Cheapest return prices found by our users on KAYAK in the last 72 hours
Sao Paulo
Sao Paulo1 stop£1,272
Rio de Janeiro
Rio de Janeiro1 stop£1,168
Lima
Lima2 stops£824
Buenos Aires
Buenos Aires2 stops£1,295
Bogotá
Bogotá2 stops£1,265
Santiago
Santiago2 stops£1,061
Quito
Quito1 stop£1,615
Sao Paulo
Sao Paulo1 stop£1,272
Rio de Janeiro
Rio de Janeiro1 stop£1,168
Lima
Lima2 stops£824
Buenos Aires
Buenos Aires2 stops£1,295
Bogotá
Bogotá2 stops£1,265
Santiago
Santiago2 stops£1,061
Quito
Quito1 stop£1,615

Book Cheap Southampton to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for return flights from Southampton to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent return flight deals from Southampton to South America

Sun, 8 Nov - Wed, 25 Nov
Delta Logo
17:30 - 07:40
SOU
-
SCL
65h 10m
2 stops
Delta Logo
23:10 - 17:00
SCL
-
SOU
38h 50m
2 stops
£1,061Delta
Wed, 4 Nov - Mon, 30 Nov
Delta Logo
17:30 - 07:40
SOU
-
SCL
41h 10m
2 stops
Delta Logo
23:10 - 08:10
SCL
-
SOU
30h 00m
2 stops
£1,111Delta
Mon, 9 Nov - Fri, 27 Nov
Delta Logo
08:40 - 07:40
SOU
-
SCL
50h 00m
2 stops
Delta Logo
23:10 - 08:55
SCL
-
SOU
30h 45m
2 stops
£1,161Delta
Mon, 13 Jul - Sun, 19 Jul
KLM Logo
09:15 - 19:45
SOU
-
GIG
14h 30m
1 stop
KLM Logo
21:55 - 08:45
GIG
-
SOU
30h 50m
1 stop
£1,168KLM
Mon, 13 Jul - Sun, 19 Jul
Multiple Airlines Logo
09:15 - 19:45
SOU
-
GIG
14h 30m
1 stop
Multiple Airlines Logo
20:50 - 17:35
GIG
-
SOU
40h 45m
2 stops
£1,194Multiple Airlines
Wed, 4 Nov - Tue, 1 Dec
Delta Logo
17:30 - 07:40
SOU
-
SCL
41h 10m
2 stops
Delta Logo
23:10 - 08:10
SCL
-
SOU
54h 00m
2 stops
£1,211Delta
Wed, 12 Aug - Sat, 7 Nov
Delta Logo
18:05 - 07:15
SOU
-
SCL
42h 10m
2 stops
Delta Logo
23:10 - 08:10
SCL
-
SOU
54h 00m
2 stops
£1,217Delta
Thu, 30 Jul - Thu, 6 Aug
KLM Logo
09:15 - 19:50
SOU
-
GRU
14h 35m
1 stop
KLM Logo
21:45 - 08:45
GRU
-
SOU
31h 00m
1 stop
£1,272KLM
Thu, 30 Jul - Thu, 6 Aug
KLM Logo
09:15 - 19:50
SOU
-
GRU
14h 35m
1 stop
KLM Logo
22:00 - 08:45
GRU
-
SOU
54h 45m
2 stops
£1,360KLM
Fri, 10 Jul - Fri, 17 Jul
KLM Logo
18:05 - 19:45
SOU
-
GIG
29h 40m
1 stop
KLM Logo
14:55 - 17:00
GIG
-
SOU
22h 05m
2 stops
£1,385KLM
Booking Insights

KAYAK's insights & trends for Southampton to South America flights

Get data-powered insights and trends into flights from Southampton to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Southampton to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 5 days.

In the past 3 days, the cheapest return tickets from Southampton to South America were found on Delta (£1,111) and KLM (£1,168).

Good to know - Cheap tickets from Southampton to South America

Cheapest flight£1,061
Flight from Southampton to Santiago

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Southampton to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Southampton to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Southampton to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Southampton to South America is likely to change within 7 days, so travellers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Southampton to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional return ticket. You could then fly from Southampton to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Southampton to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Southampton to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Southampton to South America

 
Need help choosing which airline to fly with from Southampton to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
KLMOverall score based on 1528 reviews
7.7Comfort
7.2Entertainment
7.8Boarding
7.3Food
8.4Crew
Airline reviews

The flight was 45 mins late leaving, we sat without a/c for some of this, 2nd Meal was a slice of pizza. Movies were good.

8.0 ExcellentAnonymous, Jun 2026
LHR - AMS
Read more KLM reviews

The flight was 45 mins late leaving, we sat without a/c for some of this, 2nd Meal was a slice of pizza. Movies were good.

Outstanding even though the 330 was one of the oldest in the fleet. The difference was the attentiveness and responsiveness of a really experienced flight attendant. For airline food great variety of interesting choices and good tastes supported by a good wine selection.

As per usual when you Hit the UK it's a slow process through customs Not as efficient at Thailand for sure

The flight was delayed. The aircraft was unclean. Promised seat was not given due to change in Aircraft. Not one crew on ground was in a position to give any response. Amsterdam Airport is AVIODABLE Over crowded. Over Expensive. Poor Services.

It was really nice journey i personally recommend klm flight

The crew were unprofessional with a racist element. I was physically abused as well from one of the crew members

I’m grateful for the KLM Air France shuttle bus service to Ottawa. However due to construction and other issues related to the chaotic Uber pickup system at YUL, it’s a challenge to find the Kelios bus service to Ottawa. The signs are not clear or even available. No staff to guide passengers. It’s a stressful experience.

Flight was on time, staff are friendly and helpful onboard.

Delay on my previous leg, had to run to catch my flight. But that happens. Overall ok.

Delay and had to run between flight to get my connection due to this delay but besides that the overall experience was ok. I arrived with just an hour of delay.

Everything you need to know for your flight to South America

Information on your arrival and departure airports