£354 Find Cheap Flights from Southampton to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Southampton to South America departing on 5/4. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Southampton to South America

Cheapest return prices found by our users on KAYAK in the last 72 hours
Sao Paulo
Sao Paulo2 stops£794
Buenos Aires
Buenos Aires2 stops£1,058
Lima
Lima2 stops£812
Rio de Janeiro
Rio de Janeiro1 stop£855
Bogotá
Bogotá1 stop£647
Santiago
Santiago2 stops£971
Quito
Quito2 stops£993
Florianopolis
Florianopolis3 stops£992
Sao Paulo
Sao Paulo2 stops£794
Buenos Aires
Buenos Aires2 stops£1,058
Lima
Lima2 stops£812
Rio de Janeiro
Rio de Janeiro1 stop£855
Bogotá
Bogotá1 stop£647
Santiago
Santiago2 stops£971
Quito
Quito2 stops£993
Florianopolis
Florianopolis3 stops£992

Book Cheap Southampton to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for return flights from Southampton to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent return flight deals from Southampton to South America

Fri, 13 Mar - Fri, 20 Mar
KLM Logo
17:35 - 18:25
SOU
-
GRU
27h 50m
2 stops
KLM Logo
14:40 - 08:50
GRU
-
SOU
39h 10m
2 stops
£794KLM
Fri, 13 Mar - Fri, 20 Mar
KLM Logo
17:35 - 18:25
SOU
-
GRU
27h 50m
2 stops
KLM Logo
20:59 - 08:50
GRU
-
SOU
32h 51m
1 stop
£819KLM
Sun, 15 Mar - Sun, 22 Mar
KLM Logo
09:30 - 18:40
SOU
-
GIG
36h 10m
1 stop
KLM Logo
10:50 - 17:05
GIG
-
SOU
27h 15m
2 stops
£855KLM
Sun, 15 Mar - Sun, 22 Mar
KLM Logo
17:45 - 22:45
SOU
-
GIG
32h 00m
2 stops
KLM Logo
15:55 - 17:05
GIG
-
SOU
22h 10m
2 stops
£867KLM
Sat, 28 Feb - Sun, 29 Mar
Delta Logo
17:30 - 09:55
SOU
-
GRU
43h 25m
2 stops
Delta Logo
22:50 - 08:35
GRU
-
SOU
53h 45m
2 stops
£869Delta
Sat, 28 Feb - Sat, 28 Mar
Delta Logo
17:30 - 09:55
SOU
-
GRU
43h 25m
2 stops
Delta Logo
10:40 - 15:50
GRU
-
SOU
50h 10m
2 stops
£870Delta
Fri, 13 Mar - Fri, 20 Mar
KLM Logo
17:35 - 18:25
SOU
-
GIG
27h 50m
2 stops
KLM Logo
20:45 - 08:50
GIG
-
SOU
33h 05m
2 stops
£882KLM
Sun, 15 Mar - Sun, 22 Mar
KLM Logo
09:30 - 18:40
SOU
-
GIG
36h 10m
1 stop
KLM Logo
20:50 - 17:05
GIG
-
SOU
17h 15m
1 stop
£913KLM
Fri, 13 Mar - Fri, 20 Mar
Multiple Airlines Logo
17:35 - 00:30
SOU
-
GIG
33h 55m
3 stops
Multiple Airlines Logo
09:30 - 14:50
GIG
-
SOU
26h 20m
2 stops
£946Multiple Airlines
Fri, 27 Feb - Sat, 28 Mar
Delta Logo
17:35 - 09:55
SOU
-
GRU
43h 20m
2 stops
Delta Logo
23:45 - 08:35
GRU
-
SOU
28h 50m
2 stops
£979Delta
Booking Insights

KAYAK's insights & trends for Southampton to South America flights

Get data-powered insights and trends into flights from Southampton to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Southampton to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest return tickets from Southampton to South America were found on KLM (£794) and Delta (£869).

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Southampton to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Southampton to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Southampton to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Southampton to South America is likely to change within 7 days, so travellers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Southampton to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional return ticket. You could then fly from Southampton to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Southampton to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Southampton to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Southampton to South America

 
Need help choosing which airline to fly with from Southampton to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.7
KLMOverall score based on 1443 reviews
7.1Entertainment
7.8Boarding
7.3Food
7.6Comfort
8.4Crew
Airline reviews

I’m grateful for the KLM Air France shuttle bus service to Ottawa. However due to construction and other issues related to the chaotic Uber pickup system at YUL, it’s a challenge to find the Kelios bus service to Ottawa. The signs are not clear or even available. No staff to guide passengers. It’s a stressful experience.

4.0 OkayShereen, Dec 2025
Read more KLM reviews

I’m grateful for the KLM Air France shuttle bus service to Ottawa. However due to construction and other issues related to the chaotic Uber pickup system at YUL, it’s a challenge to find the Kelios bus service to Ottawa. The signs are not clear or even available. No staff to guide passengers. It’s a stressful experience.

Flight was on time, staff are friendly and helpful onboard.

Terrible last row seats many seats available but no offer to move to better seat

Delay and had to run between flight to get my connection due to this delay but besides that the overall experience was ok. I arrived with just an hour of delay.

At the airport, terrible, I do not want to even remember it. It was too humiliating for a business class passenger.

They forgot to serve food and the crew was very unfriendly. Never experienced such a bad KLM flight. Usually fly from Toronto. New York was different.

The immigration hall in Amsterdam was understaffed, so passport checking was slower than it should be for a major airport. They need to get the automatic readers up and running for non EU passport holders. Waiting in line after a long flight feels a bit abusive.

Short flight so it was okay. Nice crew, all very pleasant and professional. We were near the back in row 27 so just as we got our drinks, we started our descent so had to drink very quickly!

KLM remains a quality flag carrier airline which maintains its standards whilst all their competitors are lowering theirs.

The baggage drop-off in Stuttgart is bad: after online check-in you cannot use the automated baggage drop off as indicated on the website. You can use the terminals but have to cue to 1 of three open and slowly working counters to drop the bags. took about 45 minutes wait time.

Everything you need to know for your flight to South America

Information on your arrival and departure airports